Format

Send to

Choose Destination
Nat Genet. 2008 Sep;40(9):1062-4. doi: 10.1038/ng.202.

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

Author information

1
Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA.

Abstract

The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE.

PMID:
19165919
PMCID:
PMC3897246
DOI:
10.1038/ng.202
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center