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Hypertens Pregnancy. 2009 Feb;28(1):85-94. doi: 10.1080/10641950802419887.

Genetic thrombophilia variants and risk for preeclampsia among American Indians.

Author information

1
Turtle Mountain Community College, Belcourt, North Dakota, USA. sbest@utma.com

Abstract

OBJECTIVE:

To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.

METHODS:

A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.

RESULTS:

The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.

CONCLUSION:

The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.

PMID:
19165673
PMCID:
PMC6097878
DOI:
10.1080/10641950802419887
[Indexed for MEDLINE]
Free PMC Article

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