Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2009 Feb 6;323(5915):802-6. doi: 10.1126/science.1165527. Epub 2009 Jan 22.

Axon regeneration requires a conserved MAP kinase pathway.

Author information

  • 1Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112-0840, USA.

Abstract

Regeneration of injured neurons can restore function, but most neurons regenerate poorly or not at all. The failure to regenerate in some cases is due to a lack of activation of cell-intrinsic regeneration pathways. These pathways might be targeted for the development of therapies that can restore neuron function after injury or disease. Here, we show that the DLK-1 mitogen-activated protein (MAP) kinase pathway is essential for regeneration in Caenorhabditis elegans motor neurons. Loss of this pathway eliminates regeneration, whereas activating it improves regeneration. Further, these proteins also regulate the later step of growth cone migration. We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth.

PMID:
19164707
PMCID:
PMC2729122
DOI:
10.1126/science.1165527
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center