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Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2194-9. doi: 10.1073/pnas.0808602106. Epub 2009 Jan 21.

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization.

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  • 1Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA.


Nucleocytoplasmic coupling is mediated by outer nuclear membrane (ONM) nesprin proteins and inner nuclear membrane Sun proteins. Interactions spanning the perinuclear space create nesprin-Sun complexes connecting the cytoskeleton to nuclear components. A search for proteins displaying a conserved C-terminal sequence present in nesprins 1-3 identified nesprin 4 (Nesp4), a new member of this family. Nesp4 is a kinesin-1-binding protein that displays Sun-dependent localization to the ONM. Expression of Nesp4 is associated with dramatic changes in cellular organization involving relocation of the centrosome and Golgi apparatus relative to the nucleus. These effects can be accounted for entirely by Nesp4's kinesin-binding function. The implication is that Nesp4 may contribute to microtubule-dependent nuclear positioning.

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