Format

Send to

Choose Destination
J Biol Chem. 2009 May 15;284(20):13285-9. doi: 10.1074/jbc.R800080200. Epub 2009 Jan 21.

Protein ionizable groups: pK values and their contribution to protein stability and solubility.

Author information

1
Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, Texas 77843, USA. nickpace@tamu.edu

Abstract

The structure, stability, solubility, and function of proteins depend on their net charge and on the ionization state of the individual residues. Consequently, biochemists are interested in the pK values of the ionizable groups in proteins and how these pK values depend on their environment. We review what has been learned about pK values of ionizable groups in proteins from experimental studies and discuss the important contributions they make to protein stability and solubility.

PMID:
19164280
PMCID:
PMC2679426
DOI:
10.1074/jbc.R800080200
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center