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J Nucl Med. 2009 Feb;50(2):239-49. doi: 10.2967/jnumed.108.056655. Epub 2009 Jan 21.

Imaging surrogates of tumor response to therapy: anatomic and functional biomarkers.

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1
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. zhaob@mskcc.org

Abstract

This article addresses the current status of quantitative imaging as a surrogate biomarker for the assessment of tumor response to therapy with non-small cell lung cancer as an example. In addition, the article discusses the limitations of conventional response criteria in the new era of molecular-targeted agents for cancer treatment; the increasing need for more accurate and early response-assessment methods, particularly for volumetric CT; new tumor-specific radiotracers and molecular imaging technologies; and the future applications of molecular imaging with PET for studying various features of cancer metabolism, endocrine status, hypoxia, and oncofetal and differentiation antigens.

PMID:
19164218
DOI:
10.2967/jnumed.108.056655
[Indexed for MEDLINE]
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