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Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2643. doi: 10.1109/IEMBS.2008.4649744.

Applications of optical resonance to biological imaging and label-free protein microarrays.

Author information

1
Departments of Electrical and Computer Engineering, Physics and Biomedical Engineering at Boston University, MA 02215, USA. selim@bu.edu

Abstract

We present biological imaging and sensing methods based on optical resonance and interference. In fluorescence microscopy, our nanoscale imaging capability sheds light onto conformational changes of DNA, DNA-protein complexes and polymer coatings on a solid surface. Interference measurements on a layered substrate yield a label-free sensing platform for protein binding in a high-throughput micro-array format.

PMID:
19163247
DOI:
10.1109/IEMBS.2008.4649744
[Indexed for MEDLINE]

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