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J Ethnopharmacol. 2009 Mar 18;122(2):379-83. doi: 10.1016/j.jep.2008.12.027. Epub 2008 Dec 30.

Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract.

Author information

1
Department of Life Sciences, National Chung Hsing University, Taiwan, ROC.

Abstract

AIM OF STUDY:

Bidens pilosa has traditionally been used as an anti-diabetic phytomedicine. However, its alleged benefits and mechanism remain elusive. This study aimed to evaluate the effect and action of Bidens pilosa water extract on type 2 diabetes.

MATERIALS AND METHODS:

A daily dose of Bidens pilosa water extract or glimepiride, a positive control, was given orally to C57BL/KsJ-db/db mice once or for 28 days. Levels of blood glucose, serum insulin, and glycosylated hemoglobulin A1C, glucose tolerance, and islet structure were used to evaluate its anti-diabetic effects in db/db mice. Rat pancreatic islets and streptozocin-treated mice were tested for insulin-releasing mechanism of Bidens pilosa water extract.

RESULTS:

A daily dose of Bidens pilosa water extract given once or for 28 days significantly decreased blood glucose levels and increased serum insulin levels in db/db mice. Besides, 28-day treatment with Bidens pilosa water extract significantly improved glucose tolerance, decreased HbA1C levels and protected islet structure in db/db mice. Mechanism study showed that Bidens pilosa water extract stimulated insulin secretion via pancreatic islets.

CONCLUSIONS:

Our results suggest that Bidens pilosa water extract ameliorates type 2 diabetes in db/db mice via regulation of insulin secretion and islet protection.

PMID:
19162158
DOI:
10.1016/j.jep.2008.12.027
[Indexed for MEDLINE]

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