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Biochim Biophys Acta. 2009 May;1793(5):888-92. doi: 10.1016/j.bbamcr.2008.12.012. Epub 2008 Dec 31.

The regulation of tenascin expression by tissue microenvironments.

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Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, California 95616, USA.


Tenascins are a family of four extracellular matrix proteins: tenascin-C, X, R and W. The four members of the family have strikingly diverse patterns of expression during development and in the adult organism indicating independent mechanisms of regulation. In this review we illustrate that there are two types of tenascins, those that are significantly regulated by the tissue microenvironment (tenascin-C and tenascin-W), and those that have stabile, restricted expression patterns (tenascin-R and tenascin-X). We summarize what is known about the regulation of tenascin expression by transforming growth factor betas, fibroblast growth factors, platelet derived growth factors, as well as pro- and anti-inflammatory cytokines or hormones that either induce or inhibit expression of tenascins.

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