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Immunol Rev. 2008 Dec;226:19-28. doi: 10.1111/j.1600-065X.2008.00697.x.

Interleukin-2 in the development and control of inflammatory disease.

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1
Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA.

Abstract

Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.

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