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Org Lett. 2009 Feb 19;11(4):999-1002. doi: 10.1021/ol8029593.

A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis.

Author information

1
Center for Insoluble Protein Structures, Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.

Abstract

Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of beta-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and (19)F-BAY94-9172.

PMID:
19161320
DOI:
10.1021/ol8029593
[Indexed for MEDLINE]

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