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J Med Chem. 2009 Feb 26;52(4):1209-13. doi: 10.1021/jm801333m.

Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.

Author information

1
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.

Abstract

New glycolipids and a benzylammonium lipid were rationally designed by varying the chemical structure of a D-glucose-derived hit compound active as lipid A antagonist. We report the synthesis of these compounds, their in vitro activity as lipid A antagonists on HEK cells, and the capacity to inhibit LPS-induced septic shock in vivo. The lack of toxicity and the good in vivo activity suggest the use of some compounds of the panel as hits for antisepsis drug development.

PMID:
19161283
DOI:
10.1021/jm801333m
[Indexed for MEDLINE]

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