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J Antibiot (Tokyo). 2008 Sep;61(9):550-5. doi: 10.1038/ja.2008.73.

Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938.

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1
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Abstract

Two new aromatic alkaloids, designated citrinamides A and B, were isolated from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis, including NMR and amino acid analysis. Citrinamides A and B showed moderate potentiation of miconazole activity against Candida albicans.

PMID:
19160522
DOI:
10.1038/ja.2008.73
[Indexed for MEDLINE]
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