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J Antibiot (Tokyo). 2008 Sep;61(9):545-9. doi: 10.1038/ja.2008.72.

A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation.

Author information

  • 1Exploratory Research Laboratories I, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. fujita.yoko.x8@daiichisankyo.co.jp

Abstract

In our screening for translocase I inhibitors, we found the novel nucleoside antibiotic, A-94964 in the culture broth of Streptomyces sp. SANK 60404. The structure of A-94964 was elucidated primarily by various NMR studies, including a 1H-31P HMBC experiment. A-94964 has a unique structure which possesses a nucleoside moiety and an N-acylglucosamine moiety connected via a phosphate.

PMID:
19160521
DOI:
10.1038/ja.2008.72
[PubMed - indexed for MEDLINE]
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