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Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006988. doi: 10.1002/14651858.CD006988.pub2.

Radioiodine therapy for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases.

Author information

1
Department of Nuclear Medicine, Affiliated Hospital of Medical College Qingdao University, Jiangsu Road 16, Qingdao, Shandong Province, China, 266003. machaopony@hotmail.com

Abstract

BACKGROUND:

Differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases has been observed in follow-up studies. The management of this condition remains controversial. Most studies support blind radioactive iodine treatment while others negate this approach.

OBJECTIVES:

To assess the effects of radioiodine therapy for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases.

SEARCH STRATEGY:

Studies were obtained from computerised searches of MEDLINE, EMBASE, The Cochrane Library, China National Infrastructure (CNKI) and paper collections of conferences held in Chinese.

SELECTION CRITERIA:

Randomised controlled clinical trials and prospective controlled clinical trials.

DATA COLLECTION AND ANALYSIS:

Two authors independently extracted data and interviewed authors of all potentially relevant studies by electronic mail to verify randomisation procedures. One author entered data into a data extraction form and the second one verified the results of this procedure.

MAIN RESULTS:

Because of the absence of any suitable randomised or prospective controlled trial in this area, results currently cannot be presented.

AUTHORS' CONCLUSIONS:

The currently available evidence is insufficient to reliably assess the potential of radioiodine treatment for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases.

PMID:
19160311
DOI:
10.1002/14651858.CD006988.pub2
[Indexed for MEDLINE]

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