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Cardiovasc Drugs Ther. 2009 Jun;23(3):235-41. doi: 10.1007/s10557-008-6160-5.

More clinical lessons from the FIELD study.

Author information

1
Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6300, USA. sergio.fazio@vanderbilt.edu

Abstract

INTRODUCTION:

The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study investigated the effect of fenofibrate treatment in 9,795 patients with type 2 diabetes.

RESULTS AND DISCUSSION:

Reduction in major coronary events (the primary endpoint) and total cardiovascular disease (CVD) events (the secondary endpoint) was similar (relative risk reduction 11%), but only significant for total CVD events (p = 0.035). The benefit of fenofibrate treatment was greater in patients with mixed dyslipidaemia, especially in those with triglycerides >2.3 mmol/L and low plasma levels of high-density lipoprotein cholesterol (relative risk reduction 27%, p = 0.005). There were also microvascular benefits associated with fenofibrate treatment, specifically reduction in the rate of laser therapy for retinopathy (by 30%, p < 0.001), non-traumatic amputation (by 38%, p = 0.011) and progression of albuminuria (p < 0.002). Fenofibrate was generally well tolerated alone or in combination with a statin.

CONCLUSIONS:

Overall, the FIELD study data support the use of fenofibrate for CVD prevention in diabetes, ideally in patients without prior macrovascular or microvascular complications. Fenofibrate may also have a role as a preventive treatment for diabetic retinopathy. Addition of fenofibrate to statin therapy may a logical progression from the FIELD study data, although the efficacy and tolerability of this approach needs to be evaluated in prospective outcome studies.

PMID:
19160032
DOI:
10.1007/s10557-008-6160-5
[Indexed for MEDLINE]
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