Format

Send to

Choose Destination
See comment in PubMed Commons below
Diabetologia. 2009 Apr;52(4):591-5. doi: 10.1007/s00125-009-1261-7. Epub 2009 Jan 22.

Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study.

Author information

1
University of Wisconsin, Madison, WI, USA.

Abstract

AIMS/HYPOTHESIS:

Despite inverse associations with insulin resistance and adiposity, adiponectin has been associated with both increased and decreased risk of cardiovascular disease. We examined whether adiponectin is associated with total and cardiovascular mortality in older adults with well-characterised body composition.

METHODS:

We analysed data from 3,075 well-functioning adults aged 69-79 years at baseline. Mortality data were obtained over 6.6 +/- 1.6 years. We used Cox proportional hazards models adjusting for covariates in stages to examine the association between adiponectin and total and cardiovascular mortality.

RESULTS:

There were 679 deaths, 36% of which were from cardiovascular disease. Unadjusted levels of adiponectin were not associated with total or cardiovascular mortality. However, after adjusting for sex and race, adiponectin was associated with an increased risk of both total mortality (hazard ratio 1.26, 95% CI 1.15-1.37, per SD) and cardiovascular mortality (hazard ratio 1.35, 95% CI 1.17-1.56, per SD). Further adjustment for study site, smoking, hypertension, diabetes, prevalent heart disease, HDL-cholesterol, LDL-cholesterol, renal function, fasting insulin, triacylglycerol, BMI, visceral fat, thigh intermuscular fat and thigh muscle area did not attenuate this association. This association between adiponectin and increased mortality risk did not vary by sex, race, body composition, diabetes, prevalent cardiovascular disease, smoking or weight loss.

CONCLUSIONS/INTERPRETATION:

Higher levels of adiponectin were associated with increased risks of total and cardiovascular mortality in this study of older persons.

PMID:
19159917
PMCID:
PMC2756826
DOI:
10.1007/s00125-009-1261-7
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center