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FEBS Lett. 1991 Sep 23;290(1-2):195-9.

NMR studies of [U-13C]cyclosporin A bound to human cyclophilin B.

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Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, IL 60064.


NMR data (1H and 13C chemical shifts, NOEs) on [U-13C]cyclosporin A bound to cyclophilin B were compared to previously published data on the [U-13C]CsA/CyPA complex [Fesik et al., (1991) Biochemistry 30, 6574-6583]. Despite only 64% sequence identity between CyPA and CyPB, the conformation and active site environment of CsA when bound to CyPA and CyPB are nearly identical as judged by the similarity of the NMR data.

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