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EMBO J. 2009 Jan 21;28(2):86-7. doi: 10.1038/emboj.2008.270.

A protein complex that regulates PtdIns(3,5)P2 levels.

Author information

1
School of Biosciences, University of Birmingham, Edgbaton, Birmingham, UK. r.h.michell@bham.ac.uk

Abstract

Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is needed for retrograde membrane trafficking from lysosomal and late endosomal compartments and its synthesis is tightly regulated. But how cells regulate PtdIns(3,5)P2 synthesis--for example, in response to hyperosmotic shock--remains unexplained. A paper from the Weisman group gives the most complete picture so far of a multiprotein complex that controls PtdIns(3,5)P2 synthesis and explains how a VAC14 mutation functionally impairs the scaffold protein at the heart of the complex and causes a neurodegenerative condition in mice.

PMID:
19158662
PMCID:
PMC2634735
DOI:
10.1038/emboj.2008.270
[Indexed for MEDLINE]
Free PMC Article

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