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FEBS Lett. 1991 Sep 9;289(2):159-62.

ADP/ATP translocator is essential only for anaerobic growth of yeast Saccharomyces cerevisiae.

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1
Cancer Research Institute, Slovak Academy of Sciences, Bratislava.

Abstract

All three genes (AAC1, AAC2 and AAC3) encoding the mitochondrial ADP/ATP translocator, were inactivated in a haploid yeast strain by a gene disruption technique. The triple mutant was still able to grow on fermentable carbon sources but only in the presence of oxygen. Under aerobic conditions neither translocator-protein nor carrier-mediated transport was detected in all mutants in which the AAC2 gene was disrupted. It was further shown that a functional AAC genes product is essential only for anaerobic growth of Saccharomyces cerevisiae but not for growth under derepressed conditions. Under anaerobic conditions a non-detectable amount of AAC3 gene product is sufficient to ensure the cell growth and multiplication.

PMID:
1915842
DOI:
10.1016/0014-5793(91)81059-h
[Indexed for MEDLINE]
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