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Org Biomol Chem. 2009 Feb 7;7(3):435-8. doi: 10.1039/b819208a. Epub 2008 Dec 11.

A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.

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1
Natural Products Discovery Group, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, Oklahoma, 73019-3032, USA.

Abstract

A new fungal metabolite, nygerone A (), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.

PMID:
19156306
DOI:
10.1039/b819208a
[Indexed for MEDLINE]
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