Format

Send to

Choose Destination
Eur J Pharmacol. 1991 Jul 9;199(3):371-3.

Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy.

Author information

1
Laboratoire de Psychophysiologie, Faculté des Sciences, Université de Nice-Sophia Antipolis, France.

Abstract

Six WAG/Rij rats, an animal model of human absence epilepsy, were injected intraperitoneally with riluzole. At 4 mg/kg, riluzole decreased the number, mean duration and spike-frequency of the spontaneously occurring discharges for 3 h. Riluzole also increased slow wave sleep at the expense of waking. As riluzole at 3 mg/kg decreased the number and spike-frequency of the discharges without inducing a sedative effect, this compound could be of therapeutic interest in human absence epilepsy.

PMID:
1915583
DOI:
10.1016/0014-2999(91)90503-i
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center