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J Hypertens. 2009 Feb;27(2):237-42. doi: 10.1097/HJH.0b013e32832258c9.

Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Author information

1
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA.

Abstract

BACKGROUND:

Several epidemiological studies have demonstrated that carotenoid concentrations relate inversely to cardiovascular disease incidence. Thus, we examined the association of circulating carotenoids with hypertension, a major macrovascular disease risk factor.

METHODS:

Black and White men and women in the Coronary Artery Risk Development in Young Adults Study, aged 18-30 years at recruitment (1985-1986) from four US cities, were investigated over 20 years. At years 0, 7, and 15, we determined the relationships of the sum of four serum carotenoids (alpha-carotene, beta-carotene, lutein/zeaxanthin, cryptoxanthin) and of lycopene with incident hypertension using proportional hazards regression models.

RESULTS:

In 4412 participants, year 0 sum of four carotenoids was significantly inversely associated with 20-year hypertension incidence after adjustment for baseline systolic blood pressure and other confounding factors (relative hazard per SD increase of sum of four carotenoids: 0.91; 95% confidence interval = 0.84-0.99). The inverse relationships persisted in time-dependent models updating year 0 sum of four carotenoids with year 7 and year 15 values (relative hazard per SD increase of sum of four carotenoids: 0.84; 95% confidence interval = 0.77-0.92). Lycopene was unrelated to hypertension in any model.

CONCLUSION:

Those individuals with higher concentrations of sum of carotenoids, not including lycopene, generally had lower risk for future hypertension.

PMID:
19155781
PMCID:
PMC2920800
DOI:
10.1097/HJH.0b013e32832258c9
[Indexed for MEDLINE]
Free PMC Article

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