Format

Send to

Choose Destination
Sci Signal. 2009 Jan 20;2(54):pe4. doi: 10.1126/scisignal.254pe4.

Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation.

Author information

1
The Laboratory of Molecular Signalling, The Babraham Research Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. pamela.lochhead@bbsrc.ac.uk

Abstract

Autophosphorylation of the activation loop in cis is an underappreciated and poorly understood mode of activation of protein kinases. Here, I describe four examples of protein kinases that are activated in this way, concentrating on their biochemical properties and how their autophosphorylation in cis is achieved.

PMID:
19155529
DOI:
10.1126/scisignal.254pe4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center