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J Psychosom Res. 2009 Feb;66(2):173-5. doi: 10.1016/j.jpsychores.2008.06.006. Epub 2008 Nov 22.

Viewing a humorous film decreases IgE production by seminal B cells from patients with atopic eczema.

Author information

1
Department of Allergy, Moriguchi-Keijinkai Hospital, Moriguchi, Osaka, Japan. kimata-keijinkai@mkc.zap.ne.jp

Abstract

OBJECTIVE:

Sperms induced IgE production by seminal B cells from patients with atopic eczema via interaction of B cells with galectin-3 on sperms. We studied the effect of viewing a humorous film on IgE production by seminal B cells cultured with sperms.

METHODS:

Twenty-four male patients with atopic eczema viewed a humorous film (Modern Times, featuring Charlie Chaplin). Just before and immediately after viewing, semen was collected, and seminal B cells and sperms were purified. Seminal B cells were cultured with sperms and IgE production was measured, while expression of galectin-3 on sperms was assessed.

RESULTS:

After viewing the humorous film, IgE production by B cells cultured with sperms was significantly decreased. Moreover, expression of galectin-3 on sperms was reduced.

CONCLUSION:

Viewing a humorous film reduced galectin-3 expression on sperms, which in turn decreased IgE production by seminal B cells cultured with sperms. These results indicate that viewing a humorous film may be helpful for the study and treatment of local IgE production and allergy in the reproductive tract.

[Indexed for MEDLINE]

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