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J Nucl Cardiol. 2009 Jan-Feb;16(1):122-34. doi: 10.1007/s12350-008-9015-3. Epub 2009 Jan 20.

Takotsubo cardiomyopathy: state-of-the-art review.

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Division of Cardiovascular Diseases, Department of Medicine, The University of Alabama at Birmingham, LHRB 306, 1530 3rd Avenue S, Birmingham, AL 35294-0007, USA.


Takotsubo cardiomyopathy (TC) is characterized by transient, often severe, left ventricular dysfunction and electrocardiographic changes that might mimic acute myocardial infarction in the absence of significant obstructive coronary artery disease. It is often encountered in elderly women after physical or emotional stress. Excessive catecholamine stimulation, metabolic abnormalities, and microcirculatory dysfunction are thought to be responsible for the manifestations of this disorder. This comprehensive review summarizes relevant published data, atypical presentations, pathophysiology, and management strategy. It also includes a review of 789 patients with TC including nine illustrative cases encountered at our institution.

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