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Eur J Clin Nutr. 1991 Jun;45(6):299-307.

Urinary riboflavin and its metabolites: effects of riboflavin supplementation in healthy residents of rural Georgia (USA).

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Department of Biochemistry, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322.


The following study was designed to provide a comprehensive assessment of urinary riboflavin and flavin metabolites before and after ingestion of a riboflavin load in normal human volunteers. With respect to riboflavin, the total flavin excretion, the flavin-to-creatinine ratio, and the response of the flavin catabolites to the supplement indicate a well-nourished population. Differences in the effects of supplementation on the specific flavin catabolites across sex and age groups are included in detail for the first time. The feasibility of the use of flavin catabolites for determination of riboflavin status should be tested further in individuals with clinical signs of ariboflavinosis.

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