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Eukaryot Cell. 2009 Mar;8(3):421-3. doi: 10.1128/EC.00374-08. Epub 2009 Jan 16.

Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans.

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1
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.

Abstract

Peroxisomal localization of the third enzyme of the penicillin biosynthesis pathway of Aspergillus nidulans, acyl-coenzyme A:IPN acyltransferase (IAT), is mediated by its atypical peroxisomal targeting signal 1 (PTS1). However, mislocalization of IAT by deletion of either its PTS1 or of genes encoding proteins involved in peroxisome formation or transport does not completely abolish penicillin biosynthesis. This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum.

PMID:
19151327
PMCID:
PMC2653248
DOI:
10.1128/EC.00374-08
[Indexed for MEDLINE]
Free PMC Article
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