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Ann Clin Biochem. 2009 Mar;46(Pt 2):167-9. doi: 10.1258/acb.2008.008151. Epub 2009 Jan 16.

Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia.

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  • 1Department of Endocrinology, Christchurch Public Hospital, Christchurch, New Zealand. Belinda.Robb@cdhb.govt.nz

Abstract

Iron-induced renal phosphate wasting, hypophosphataemia and osteomalacia have previously been reported in a small number of Japanese patients receiving parenteral iron sucrose. We report the case history of a European male who, as a result of regular intravenous iron polymaltose, developed prolonged hypophosphataemia complicated by widespread insufficiency fractures. The pathogenesis of this complication remains unknown however our novel finding of a marked elevation in fibroblast growth factor 23 (FGF23), which normalized after ceasing parenteral iron, suggests an important and previously unreported effect of iron on FGF23 homeostasis.

PMID:
19151167
DOI:
10.1258/acb.2008.008151
[PubMed - indexed for MEDLINE]
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