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J Am Acad Dermatol. 2009 Feb;60(2):315-20. doi: 10.1016/j.jaad.2008.08.035.

Acquired epidermodysplasia verruciformis.

Author information

1
Department of Dermatology, Columbia University Medical Center, New York, New York, USA. hr2121@columbia.edu

Abstract

Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis with an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, this viral infection leads to the development of tinea versicolor-like macules on the trunk, neck, arms, and face during childhood, and over time, these lesions can progress to squamous cell carcinoma. More recently, an EV-like syndrome has been described in patients with impaired cell-mediated immunity. We describe two cases of EV-like syndrome in HIV-positive patients, review all previously reported cases of EV in patients with impaired cell-mediated immunity, introduce the term "acquired epidermodysplasia verruciformis" to describe EV developing in the immunocompromised host and examine the limited treatment options for these patients.

PMID:
19150275
DOI:
10.1016/j.jaad.2008.08.035
[Indexed for MEDLINE]

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