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J Perinatol. 2009 May;29(5):343-51. doi: 10.1038/jp.2008.229. Epub 2009 Jan 15.

Early interventions involving parents to improve neurodevelopmental outcomes of premature infants: a meta-analysis.

Author information

1
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.

Abstract

OBJECTIVE:

To determine in a systematic review, whether interventions for infant development that involve parents, improve neurodevelopment at 12 months corrected age or older.

STUDY DESIGN:

Randomized trials were identified where an infant intervention was aimed to improve development and involved parents of preterms; and long-term neurodevelopment using standardized tests at 12 months (or longer) was reported.

RESULT:

Identified studies (n=25) used a variety of interventions including parent education, infant stimulation, home visits or individualized developmental care. Meta-analysis at 12 months (N=2198 infants) found significantly higher mental (N=2198) and physical (N=1319) performance scores favoring the intervention group. At 24 months, the mental (N=1490) performance scores were improved, but physical (N=1025) performance scores were not statistically significant. The improvement in neurodevelopmental outcome was not sustained at 36 months (N=961) and 5 years (N=1017).

CONCLUSION:

Positive clinically meaningful effects (>5 points) are seen to an age of 36 months, but are no longer present at 5 years.

PMID:
19148113
DOI:
10.1038/jp.2008.229
[Indexed for MEDLINE]

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