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Ophthalmic Res. 2009;41(2):118-22. doi: 10.1159/000192082. Epub 2009 Jan 16.

Corneal penetration into rabbit aqueous humor is comparable between preserved and preservative-free tafluprost.

Author information

1
Santen Oy, Tampere, Finland. pertti.pellinen@santen.fi

Abstract

BACKGROUND:

Some studies have shown that benzalkonium chloride (BAK), a preservative used in antiglaucoma medications, can increase corneal permeability by acting as a penetration enhancer. Tafluprost is a new prostaglandin F(2)(alpha) analog in clinical use for the treatment of ocular hypertension and glaucoma.

METHODS:

This study evaluated the corneal penetration of preservative-free tafluprost 0.0015% eye drops and tafluprost 0.0015% eye drops preserved with 0.01% BAK into the aqueous humor of rabbits.

RESULTS:

After the administration of a single topical dose (30 microl), the maximum concentrations at 45 min of tafluprost acid in aqueous humor were 4.50 ng/ml for preservative-free tafluprost and 3.99 ng/ml for preserved tafluprost. The area under the concentration-time curves from 45 min to 3 h was 5.14 ng h/ml for the preservative-free formulation and 4.54 ng h/ml for the preserved formulation.

CONCLUSIONS:

These data indicate that BAK does not affect the corneal penetration of tafluprost into the rabbit aqueous humor.

PMID:
19147999
DOI:
10.1159/000192082
[Indexed for MEDLINE]

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