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Fertil Steril. 2010 Mar 1;93(4):1248-54. doi: 10.1016/j.fertnstert.2008.12.007. Epub 2009 Jan 14.

Prediction of developing metabolic syndrome after gestational diabetes mellitus.

Author information

1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University Medical School, Izmir 35340, Turkey. baris.akinci@deu.edu.tr

Abstract

OBJECTIVE:

To determine the predictors of subsequent development of metabolic syndrome (MS) in women with previous gestational diabetes mellitus (GDM).

DESIGN:

Controlled clinical study.

SETTING:

University hospital.

PATIENT(S):

One hundred sixty-four consecutive women with previous GDM were evaluated after a mean follow-up of 40.54 months from index pregnancy. Sixty-five lean women with negative screening for GDM were included as a control group.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Subjects were evaluated for diagnosis of MS according to criteria of the National Cholesterol Education Program and the International Diabetes Federation. Tests were performed including a 75-g oral glucose tolerance test (OGTT), fasting insulin, lipids, plasma fibrinogen, blood pressure, and body measurements. The homeostasis model assessment score was calculated.

RESULT(S):

The MS prevalence was higher in women with previous GDM, according to both definitions. Univariate analysis showed that prepregnancy obesity, weight gain during follow-up, and fasting glucose level at the OGTT of the index pregnancy were predictors of developing MS. Multivariate analysis showed that fasting glucose level >100 mg/dL at the OGTT of the index pregnancy was an independent predictor of the MS development.

CONCLUSION(S):

We suggest that early prediction of women with previous GDM who are at high risk for developing MS is possible, and it is vital to prevent MS-related complications.

[Indexed for MEDLINE]

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