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Biol Blood Marrow Transplant. 2009 Jan;15(1 Suppl):120-7. doi: 10.1016/j.bbmt.2008.10.004.

Methods for equivalence and noninferiority testing.

Author information

1
Department of Statistics, University of Sao Paulo, Sao Paulo, SP, Brazil.

Abstract

Classical hypothesis testing focuses on testing whether treatments have differential effects on outcome. However, sometimes clinicians may be more interested in determining whether treatments are equivalent or whether one has noninferior outcomes. We review the hypotheses for these noninferiority and equivalence research questions, consider power and sample size issues, and discuss how to perform such a test for both binary and survival outcomes. The methods are illustrated on 2 recent studies in hematopoietic cell transplantation.

PMID:
19147090
PMCID:
PMC2701110
DOI:
10.1016/j.bbmt.2008.10.004
[Indexed for MEDLINE]
Free PMC Article

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