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Neuron. 2009 Jan 15;61(1):35-41. doi: 10.1016/j.neuron.2008.11.016.

Local origin of field potentials in visual cortex.

Author information

1
Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA.

Abstract

The local field potential (LFP) is increasingly used to measure the combined activity of neurons within a region of tissue. Yet, available estimates of the size of this region are highly disparate, ranging from several hundred microns to a few millimeters. To measure the size of this region directly, we used a combination of multielectrode recordings and optical imaging. We determined the orientation selectivity of stimulus-evoked LFP signals in primary visual cortex and were able to predict it on the basis of the surrounding map of orientation preference. The results show that > 95% of the LFP signal originates within 250 microm of the recording electrode. This quantitative estimate indicates that LFPs are more local than often recognized and provides a guide to the interpretation of the increasing number of studies that rest on LFP recordings.

PMID:
19146811
PMCID:
PMC2730490
DOI:
10.1016/j.neuron.2008.11.016
[Indexed for MEDLINE]
Free PMC Article

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