Audiogenic epilepsy in young mice of different strains after neonatal semax treatment

O S Boyarshinova; O V Perepelkina; N V Markina; I I Poletaeva

doi:10.1007/s10517-008-0212-5

Audiogenic epilepsy in young mice of different strains after neonatal semax treatment

Bull Exp Biol Med. 2008 Jul;146(1):86-8. doi: 10.1007/s10517-008-0212-5.

Authors

O S Boyarshinova¹, O V Perepelkina, N V Markina, I I Poletaeva

Affiliation

¹ Laboratory of Behavioral Physiology and Genetics, Biological Faculty, M. V. Lomonosov Moscow University, Russia.

PMID: 19145359
DOI: 10.1007/s10517-008-0212-5

Abstract

Neonatal (from day 2 to day 7 of life) injection of neuropeptide semax to mice of 5 inbred strains significantly reduced predisposition to audiogenic epilepsy in only one-month-old DBA/2J mice, which manifested in changes in the mean audiogenic sensitivity score and percentage of animals dead as a result of acoustic stimulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acoustic Stimulation
Adrenocorticotropic Hormone / analogs & derivatives*
Adrenocorticotropic Hormone / therapeutic use
Animals
Animals, Newborn
Disease Susceptibility
Epilepsy, Reflex / drug therapy*
Epilepsy, Reflex / genetics
Epilepsy, Reflex / prevention & control*
Female
Humans
Male
Mice
Mice, Inbred Strains*
Neuroprotective Agents / therapeutic use*
Peptide Fragments / therapeutic use*
Rats
Rats, Wistar

Substances

Neuroprotective Agents
Peptide Fragments
ACTH (4-7), Pro-Gly-Pro-
Adrenocorticotropic Hormone