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Cytogenet Cell Genet. 1991;57(2-3):112-3.

In situ hybridization of two markers closely flanking the spinal muscular atrophy gene to 5q12----q13.3.

Author information

1
Unité de Recherches de Physiopathologie Chromosomique, INSERM U-242, Hôpital de La Timone, Marseille, France.

Abstract

In order to refine the physical location of the p105-153Ra and M4 probes which closely flank the spinal muscular atrophy gene (SMA) on human chromosome 5q, in situ hybridization has been carried out on prometaphase chromosomes. Our results demonstrate that the disease gene is located between the 5q12----q13.1 and 5q13.3 bands. The present study will hopefully contribute to microdissection of the chromosomal region of the SMA gene.

PMID:
1914518
DOI:
10.1159/000133125
[Indexed for MEDLINE]

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