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The proteasome: overview of structure and functions.

Author information

1
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Japan. tanaka-kj@igakuken.or.jp

Abstract

The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated proteolysis in eukaryotic cells. The highly organized proteasome plays a prominent role in the control of a diverse array of basic cellular activities by rapidly and unidirectionally catalyzing biological reactions. Studies of the proteasome during the past quarter of a century have provided profound insights into its structure and functions, which has appreciably contributed to our understanding of cellular life. Many questions, however, remain to be elucidated.

PMID:
19145068
PMCID:
PMC3524306
DOI:
10.2183/pjab.85.12
[Indexed for MEDLINE]
Free PMC Article

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