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Am J Reprod Immunol. 2009 Feb;61(2):175-82. doi: 10.1111/j.1600-0897.2008.00679.x.

Glycation endproducts, soluble receptor for advanced glycation endproducts and cytokines in diabetic and non-diabetic pregnancies.

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1
Foetal-Maternal Medicine and Gynaecology Department, Research Institute Polish Mother's Memorial Hospital (RI PMMH), Lodz, Poland.

Abstract

PROBLEM:

Cytokines, advanced glycation end products (AGEs), and their receptor RAGE have been recently suggested to play a role in human pregnancy. In this study, we sought to determine the alterations of plasma AGEs, soluble RAGE (sRAGE), and proinflammatory cytokines in normal pregnancies and those complicated with type 1 diabetes mellitus.

METHOD OF STUDY:

These parameters were measured in samples from healthy non-pregnant (C), diabetic non-pregnant (D), healthy pregnant (HP), and pregnant diabetic (DP) women.

RESULTS:

In the first trimester, DP showed lower sRAGE and higher AGEs compared to HP. In the DP group, significant negative correlations were seen between TNF-alpha and lipopolysaccharide (LPS)-stimulated IotaL-6 in the first trimester and sRAGE in the third trimester. LPS-stimulated IL-12 was positively correlated with levels of AGEs in the third trimester.

CONCLUSION:

We detected several differences in the levels of AGEs, sRAGE, and proinflammatory cytokines between euglycemic and diabetic pregnancies.

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