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J Infect Dis. 2009 Feb 15;199(4):580-9. doi: 10.1086/596557.

Selection of HIV variants with signature genotypic characteristics during heterosexual transmission.

Author information

1
Brigham and Women's Hospital, Boston, Massachusetts, USA. msagar@partners.org

Abstract

BACKGROUND:

Newly infected subjects acquire a limited number of human immunodeficiency virus type 1 (HIV-1) variants with specific genotypic and phenotypic features from the array of viruses present in a chronically infected transmitting partner.

METHODS:

We examined HIV-1 envelope sequences from the earliest available serum sample after HIV-1 acquisition in 13 newly infected subjects and from their epidemiologically linked HIV-1-infected heterosexual partner. Samples from both members were collected on the same day in the Rakai Community Cohort Study.

RESULTS:

Ten couples were infected with subtype D HIV-1, and 3 pairs had subtype A HIV-1. Newly infected subjects acquired a subset of the viruses that were circulating in the transmitting partner; transmitted variants had less diversity and divergence and were more closely related to the ancestral sequences. The majority of signature amino acid differences among donor and recipient sequences were in and immediately following the V3 loop. Envelopes from recipients were significantly shorter and had a lower V3 charge than envelopes from donors, but there was no significant difference in the number of potential N-linked glycosylation sites.

CONCLUSION:

A minority subset of HIV-1 variants with signature genotypes is favored for transmission in this population.

PMID:
19143562
PMCID:
PMC2755256
DOI:
10.1086/596557
[Indexed for MEDLINE]
Free PMC Article

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