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Clin Infect Dis. 2009 Feb 15;48(4):489-92. doi: 10.1086/596503.

Effects of omeprazole on plasma levels of raltegravir.

Author information

1
Merck & Co., Whitehouse Station, Rahway, NJ 07065-0900, USA. marian_iwamoto@merck.com

Abstract

Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with omeprazole coadministration in healthy subjects; this is likely secondary to an increase in bioavailability attributable to increased gastric pH. Increased gastric pH has been reported in HIV-1-infected individuals, and the effects of omeprazole in this intended population may be diminished. Further investigation is necessary.

PMID:
19143531
DOI:
10.1086/596503
[Indexed for MEDLINE]

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