Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann Nucl Med. 2008 Dec;22(10):869-76. doi: 10.1007/s12149-008-0196-2. Epub 2009 Jan 8.

Validation of fast-RAMLA in clinical PET.

Author information

  • 1Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-0022, Japan. chobidog@nms.ac.jp

Abstract

OBJECTIVE:

Images using the fast row action maximum likelihood algorithm (fast-RAMLA), which employs half-interpolated sinograms of conventional 3DRAMLA, are immediately generated following positron emission tomography (PET) scanning and are invariably produced in the process of line-of-response RAMLA (LOR-RAMLA) reconstruction. We quantitatively and visually compared the clinical validity of dual time point [(18)F]-FDG imaging with fast-RAMLA and LOR-RAMLA.

METHODS:

An International Electrotechnical Commission (IEC) phantom was established in which the ratio of the activities in the hot sphere was set up and a background of 3.8:1 was scanned and reconstructed using both algorithms. The contrast recovery coefficient was then calculated. The clinical study retrospectively analyzed 35 patients (25 men and 10 women; age range 30-84 years; mean age 63.9 years) with confirmed specific pathological lesions or clinical follow-up; 21 of the patients had 51 malignant lesions and 15 had 23 benign lesions. The maximum standard uptake value (SUV(max)) was measured in all lesions using LOR-RAMLA. The maximal counts of all lesions determined manually were divided by the average count of bilateral ventricles and the aortic arch for standardization on fast-RAMLA, and the values were compared with the SUV(max) of LORRAMLA. Inter-observer variation in detection was determined among three radiologists who blindly reviewed and scored 70 maximum intensity projection images from 35 patients reconstructed using LORRAMLA and fast-RAMLA.

RESULTS:

We identified a quantitative correlation and determined the visual quality of lesion detection between fast-RAMLA and LOR-RAMLA and indicated usefulness and improvement point on fast-RAMLA.

CONCLUSIONS:

Fast-RAMLA can improve the strategy for using dual time point [(18)F] fluorodeoxyglucose positron emission tomography ([(18)F]-FDG-PET) and increase the efficiency of the [(18)F]-FDG-PET scanner.

PMID:
19142705
DOI:
10.1007/s12149-008-0196-2
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center