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Virology. 2009 Feb 20;384(2):360-8. doi: 10.1016/j.virol.2008.11.032. Epub 2009 Jan 13.

Papillomavirus DNA replication - from initiation to genomic instability.

Author information

1
Institute of Technology, University of Tartu, Estonia.

Abstract

Papillomaviruses establish their productive life cycle in stratified epithelium or mucosa, where the undifferentiated proliferating keratinocytes are the initial targets for the productive viral infection. Papillomaviruses have evolved mechanisms to adapt to the normal cellular growth control pathways and to adjust their DNA replication and maintenance cycle to contend with the cellular differentiation. We provide overview of the papillomavirus DNA replication in the differentiating epithelium and describe the molecular interactions important for viral DNA replication on all steps of the viral life cycle.

PMID:
19141359
DOI:
10.1016/j.virol.2008.11.032
[Indexed for MEDLINE]
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