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Curr Opin Microbiol. 2009 Feb;12(1):81-7. doi: 10.1016/j.mib.2008.11.009. Epub 2009 Jan 8.

Effector protein modulation of host cells: examples in the Chlamydia spp. arsenal.

Author information

1
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

Abstract

As obligate intracellular parasites, Chlamydia spp. must create and maintain a specialized intracellular niche while simultaneously contending with potent host defenses. Discoveries that chlamydiae deploy an array of anti-host proteins have placed new emphasis on deciphering the impact of host cell biology on chlamydial development and virulence. Recent advances in the understanding of chlamydial pathogenesis are exemplified by work describing potential roles of (i) chlamydial Tarp in invasion, (ii) Inc proteins in modulation of vesicular interactions, and (iii) chlamydial proteins in disregulation of NF-kappaB signal transduction. Characterization of these chlamydial effector proteins promises to answer old questions and reveals previously unappreciated biology. The challenge will be to determine how these molecular mechanisms mesh together and collectively contribute to Chlamydia-mediated disease.

PMID:
19138553
DOI:
10.1016/j.mib.2008.11.009
[Indexed for MEDLINE]

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