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J Drugs Dermatol. 2008 Dec;7(12):1149-52.

Subantimicrobial-dose doxycycline in the treatment of moderate facial acne.

Author information

1
Skin Research Center, Shahid Beheshti Medical University, Shohada-e Tajrish Hospital,Tehran, Iran.

Abstract

BACKGROUND:

Acne is a common inflammatory skin disorder. Oral antibiotics play a significant clinical role in treating acne.

OBJECTIVE:

The purpose of this study was to compare the efficacy of doxycycline at antimicrobial and subantimicrobial doses for the treatment of acne.

METHODS:

A prospective, randomized, double-blind, controlled trial was performed. One hundred patients with moderate facial acne were randomized into 2 treatment groups, one receiving a tablet containing 20 mg of doxycycline to be taken twice daily and the other receiving a tablet containing 100 mg of doxycycline and a matching placebo tablet to be taken twice daily.

RESULTS:

Subantimicrobial-dose doxycycline administered twice daily for 3 months in patients with moderate inflammatory acne results in significant reduction in the number of total inflammatory lesions. There was an 84% reduction in number of papules and a 90% reduction in number of pustules with treatment.

CONCLUSION:

Subantimicrobial-dose doxycycline is an effective treatment for patients with moderate acne vulgaris.

PMID:
19137768
[Indexed for MEDLINE]

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