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Nat Neurosci. 2009 Feb;12(2):113-5. doi: 10.1038/nn.2244. Epub 2009 Jan 11.

Neuronal release of proBDNF.

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1
Department of Medicine, Weill Cornell Medical College, 1300 York Ave., New York, New York 10065, USA.

Abstract

Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.

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PMID:
19136973
PMCID:
PMC2737352
DOI:
10.1038/nn.2244
[Indexed for MEDLINE]
Free PMC Article

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