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Pharmacol Ther. 2009 Apr;122(1):9-18. doi: 10.1016/j.pharmthera.2008.12.001. Epub 2008 Dec 24.

GDNF--a potential target to treat addiction.

Author information

1
The Ernest Gallo Research Center, University of California, San Francisco, Emeryville, CA 94608, USA.

Abstract

The glial cell line-derived neurotrophic factor (GDNF) is a secreted protein, best known for its role in the development of the central and peripheral nervous systems and the survival of adult dopaminergic neurons. More recently, accumulating evidence suggests that GDNF plays a unique role in negatively regulating the actions of drugs of abuse. In this article, we review these data and highlight the possibility that the GDNF pathway may be a promising target for the treatment of addiction.

PMID:
19136027
PMCID:
PMC3682485
DOI:
10.1016/j.pharmthera.2008.12.001
[Indexed for MEDLINE]
Free PMC Article

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