Format

Send to

Choose Destination
Trends Neurosci. 2009 Feb;32(2):69-72. doi: 10.1016/j.tins.2008.11.002. Epub 2009 Jan 8.

Contact in the genetics of autism and schizophrenia.

Author information

1
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, P.O. Box 85060, 3508 AB Utrecht, The Netherlands. j.p.h.burbach@umcutrecht.nl <j.p.h.burbach@umcutrecht.nl>

Abstract

Although autism and schizophrenia are considered to be distinct neuropsychiatric developmental disorders, recent studies indicate that they share genetic factors. The same chromosomal rearrangements and several single genes have emerged as genetic risks in both disorders. One such gene is contactin-associated protein-2 (CNTNAP2). These findings raise the possibility that these neuropsychiatric disorders share pathogenic mechanisms and that similar defects in biological pathways of brain development might underlie the phenotypic spectrum of these disorders.

PMID:
19135727
DOI:
10.1016/j.tins.2008.11.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center