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Mov Disord. 2009 Feb 15;24(3):455-9. doi: 10.1002/mds.22442.

FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.

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1
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA. wider.christian@mayo.edu

Abstract

Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels.

PMID:
19133659
PMCID:
PMC2875476
DOI:
10.1002/mds.22442
[Indexed for MEDLINE]
Free PMC Article
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