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J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):206-14. doi: 10.1097/QAI.0b013e318190018c.

Interleukine-2 therapy does not increase the risk of Hodgkin or non-Hodgkin lymphoma in HIV-infected patients: results from FHDH ANRS CO4.

Collaborators (214)

Abgrall S, Barin F, Bentata M, Billaud E, Boué F, Burty C, Cabié A, Cotte L, De Truchis P, Duval X, Enel P, Fredouille-Heripret L, Gasnault J, Gaud C, Gilquin J, Grabar S, Katlama C, Khuong M, Lang JM, Lascaux A, Launay O, Mahamat A, Mary-Krause M, Matheron S, Meynard J, Pavie J, Pialoux G, Pilorgé F, Reynes J, Rouveix E, Simon A, Tattevin P, Tissot-Dupont H, Viard J, Viget N, Pariente-Khayat A, Salomon V, Jacquemet N, Rivet A, Abgrall S, Grabar S, Guiguet M, Lanoy E, Lièvre L, Mary-Krause M, Potard V, Selinger-Leneman H, Fichou J, Bouvet E, Crickx B, Ecobichon J, Leport C, Matheron S, Picard-Dahan C, Yeni P, Tisne-Dessus D, Salmon D, Sicard D, Auperin I, Gilquin J, Roudière L, Viard J, Boué F, Fior R, Delfraissy J, Goujard C, Jung C, Lesprit P, Desplanque N, Meynard JL, Meyohas M, Picard O, Cadranel J, Mayaud C, Pialoux G, Bricaire F, Herson S, Katlama C, Simon A, Clauvel J, Decazes JM, Gerard L, Molina JM, Diemer M, Sellier P, Berthé H, Dupont C, Chandemerle C, Mortier E, de Truchis P, Bentata M, Honoré P, Jeantils V, Tassi S, Mechali D, Taverne B, Gourdon F, Laurichesse H, Fresard A, Lucht F, Eglinger P, Faller JP, Bazin C, Verdon R, Boibieux A, Peyramond D, Livrozet JM, Touraine J, Cotte L, Trepo C, Ravaux I, Tissot-Dupont H, Delmont J, Moreau J, Gastaut J, Retornaz F, Soubeyrand J, Allegre T, Blanc P, Galinier A, Ruiz J, Lepeu G, Granet-Brunello P, Esterni J, Pelissier L, Cohen-Valensi R, Nezri M, Chadapaud S, Laffeuillade A, Reynes J, May T, Rabaud C, Billaud E, Raffi F, Pugliese P, Arvieux C, Michelet C, Borsa-Lebas F, Caron F, Fraisse P, Lang J, Rey D, Arlet-Suau E, Cuzin L, Massip P, Thiercelin Legrand M, Yazdanpanah Y, Pradinaud R, Sobesky M, Gaud C, Contant M, Lévy Y, Aboulker J, Bursachi P, Delfraissy J, Saïdi Y, Lascaux A, Saïdi S, Commoy M, Chêne G, Viard JP, Molina J, Tubiana R, Lascaux AS, Berdah M, Jung C, Molina J, Lafaurie M, Schnell-Niedbalski L, Oksenhendler E, Gérard L, Delfraissy J, Goujard C, Chaix F, Rannou MT, Tegna L, Tisne-Dessus D, Jeanblanc F, Beck-Wirth G, Benomar M, Verdon R, Bazin C, Goubin P, Girard P, Boudraa C, Sebire M, Viard J, Maignan A, Tubiana R, Katlama C, Curjol A, Fabre G, Trepo C, Brochier C, Thoirain V, Bloch M, Mortier E, Dupon M, Raymond I, Ragnaud JM, Raymond I, Sellier P, Magnier JD, Simon A, Iguerstira M, Gastaut J, Dalmas AM, Aboulker J, Guéguen S, Circosta S, Mourlhou P, Saouzanet-Harel M, Izard S, Saïdi Y.

Author information

1
Centre Hospitalier Universitaire de Nice, Département de santé publique, Nice, F-06003, France. fontas.e@chu-nice.fr

Abstract

BACKGROUND:

Concerns have been raised about a possible excess risk of lymphomas in HIV-infected patients exposed to interleukin 2 (IL-2) therapy. Here we compared the risks of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) in IL-2-treated and IL-2-untreated HIV-infected patients.

METHODS:

Patients monitored through the French Hospital Database on HIV between May 1, 1995, and December 31, 2005, were enrolled in this study. Lymphomas that occurred between the day after study entry and the end of follow-up were eligible for analysis. Poisson regression models were used in 2 separate analyses to quantify the possible relationship between IL-2 therapy and the incidence of NHL and HL.

RESULTS:

The IL-2-treated group consisted of 861 patients and the IL-2-untreated group of 77,605 patients. Follow-up lasted a total of 3643 and 382,720 person-years, respectively. After adjustment for sex and time-updated age, period, the CD4 cell counts, the plasma HIV RNA levels, and AIDS status, the relative rates of NHL and HL associated with IL-2 therapy were 0.64 (95% confidence interval, 0.25 to 1.65) and 0.33 (95% confidence interval, 0.04 to 2.86), respectively.

CONCLUSIONS:

In this large observational study, IL-2 therapy did not increase the risk of lymphoma, either NHL or HL, in HIV-infected patients.

PMID:
19131886
DOI:
10.1097/QAI.0b013e318190018c
[Indexed for MEDLINE]

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